Plasminogen activators: From cloning to therapy
نویسندگان
چکیده
منابع مشابه
Bacterial plasminogen activators and receptors.
Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and th...
متن کاملPurification of plasminogen activators from human seminal plasma.
Two plasminogen activators (1 and 2) were isolated from human seminal plasma by hiigh-speed centrifugation, Sephadex-gel filtration and ion-exchange chromatography. The activators were shown to be homogeneous by polyacrylamide-disc -gel electrophoresis at pH 8.3 and 4.5, and by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. The molecular weights of activators 1 and 2 were estimated...
متن کاملPlasminogen activators and plasminogen activator inhibitors in endometriosis.
Endometriosis is one of the most frequent benign gynecological diseases that affect women. Little is known about the pathogenesis and etiology of endometriosis, despite the numerous studies performed in this field. Although endometriosis is a benign disease, the endometrial tissue, after attachment to the peritoneum, has the ability to grow and invade the surrounding tissues. Similar to neoplas...
متن کاملBinding of plasminogen activators to fibrin: characterization and pharmacological consequences.
The fibrinolytic pathway maintains vascular patency by the proteolytic degradation of fibrin, the end-product of coagulation. Formation of a fibrin mesh during haemostasis is part of the physiological response to vascular injury, whereas thrombosis is a pathological obstruction of blood flow, but the biochemical and cellular participants are believed to be similar. Physiological fibrinolysis is...
متن کاملApproaches to Thrombolysis Plasminogen Activators in Ischemic Stroke Introduction
A number of plasminogen activators (PAs), enzymes capable of converting the zymogen plasminogen to the active agent plasmin, have been studied as potential therapeutic agents in the settings of ischemic stroke, intracerebral parenchymal hemorrhage, and large vessel thrombosis. Several have found purpose in the acute management of focal cerebral ischemia under strictly limited conditions. All de...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1992
ISSN: 0014-5793
DOI: 10.1016/0014-5793(92)81154-e